Testosterone propionate, for intramuscular injection, contains testosterone propionate which is the oil-soluble 4-androstene-3-one,17beta-ol of the androgenic hormone testosterone. Testosterone propoinate is attached to a short ester. Thus, 100mg of testosterone propionate contains 83.72mg of testosterone, more testosterone than in any other ester-based testosterone preparation of equivalent overall dosage.
Testosterone propionate is used in males to treat primary hypogonadism (congenital or acquired) – testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, or orchidectomy. In females: metastatic mammary cancer. Testosterone propionate converts into estrogens and DHT.
Dosage and administration
Adult: males 50-100mg per week; females, in case of mammary cancer, 50-100mg every 2 to 4 weeks. Active life: 2-3 days.
Androgens are contraindicated in men with carcinomas of the breast or with known or suspected carcinomas of the prostate and in women who are or may become pregnant.
Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis.